CJC-1295 (with DAC)

$75.00

CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH 1-29) engineered with a drug affinity complex (DAC) moiety that promotes reversible binding to serum albumin, significantly extending its plasma half-life and duration of action compared to unmodified GHRH fragments.
  • Structure: Modified GHRH(1-29) with DAC extension for prolonged activity
  • Key Modification: Albumin-binding domain for extended pharmacokinetics
  • Research Applications: Pituitary somatotroph stimulation, pulsatile GH patterns, IGF-1 pathway exploration
  • Common Models: Rodent and primate pituitary function studies, metabolic homeostasis experiments
  • Mechanistic Interests: cAMP accumulation, GHRH receptor activation, long-term GH axis modulation
It is used in research to investigate sustained pituitary growth hormone release, cyclic AMP-mediated signaling cascades, somatotropic axis dynamics, and endocrine feedback regulation in preclinical endocrine and metabolic model systems.
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cjc 1295 (with dac)